Two girls were "seriously" injured in the 15:20 GMT crash in Belvidere Road, according to the emergency services.
The driver of the Peugeot car, a woman in her 80s, was also injured and treated at the scene.
Seven of the girls, aged between 11 and 13, were taken to Alder Hey children's hospital by ambulance.
A 16-year-old with minor injuries was taken to The Royal Liverpool University Hospital.
'Broken bones'
Merseyside Police said the driver, who stopped at the scene, was not injured and had not been arrested. She is assisting police with inquiries.
Merseyside Police said none of the girls was thought to be in a life-threatening condition.
Six of the girls have serious injuries consisting of broken bones and, in the case of one 11-year-old, a head injury.
One 13-year-old has a fractured hip and another has two broken arms.
Belvedere Academy, a nearby girls school,posted a statement on its website which said: "Unfortunately there was a serious accident outside the Academy.
"Six of our students sustained injuries, some quite serious but not life-threatening. The emergency services were on the scene very quickly and dealt efficiently with the situation."
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